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Article ID 14390
Title of the Article/ Research work MALARIA: NOVEL PLANT REMEDIES SHOW GREAT PROMISE IN TREATING THE DEADLY DISEASE
Journal Global Journal of Research on Medicinal Plants & Indigenous Medicine (GJRMI) | Year : 2012 | Volume : 1 | Issue : 3 | Pages : 62-68
Author(s) Taba K.M.1 , Paulus J. 2, Kayembe J.S.1
Designation & Institution 1University of Kinshasa, Faculty of Sciences, Dept of Chemistry P.O. Box 190 Kinshasa XI, Democratic Republic of Congo; 2University of Kinshasa, Faculty of Sciences, Dept of Biology P.O. Box 190 Kinshasa XI, Democratic Republic of Congo.
Corresponding address Taba K.M., University of Kinshasa, Faculty of Sciences, Dept of Chemistry P.O. Box 190 Kinshasa XI, Democratic Republic of Congo. Tel. 243 81 333 02 42 email: tabakalulu@yahoo.fr
Disease related
(if any)
MALARIA(ICPC-A73|ICD-B50, B51, B52, B53, B54)
Keywords Malaria, Plant Remedies, Cassia occidentalis Linn.,Carica Papaya Linn., Cymbopogon citratus (DC.) Staff, 1906, Garcinia kola Heckel., Lantana camara L., Ocimum gratissimum L., Phyllanthus niruri L., Vernonia amygdalina Delile.
Full Paper URL http://www.gjrmi.com/Upload/Issue3/Taba%20K%20M%20et%20al.%20GJRMI%201%283%29%2062-68.pdf
   
Abstract / Details / Synopsis
Clinical investigation of eight plant remedies used as traditional medicines in Kinshasa, D.R. Congo, to treat Malaria patients showed significant removal of parasites in the blood, as well as elimination of clinical detection of disease. The percentage recovery from Malaria depends on the type of remedy chosen: Cassia occidentalis Linn. (97%), Carica Papaya Linn. (94%), Cymbopogon citratus (DC.) Staff, 1906 (93%), Garcinia kola Heckel. (94%), Lantana camara L. (90%), Ocimum gratissimum L. (86%), Phyllanthus niruri L. (93%) and Vernonia amygdalina Delile. (67%). No identifiable side effects were noticed during and after treatment. In vitro study of alcohol extracts of these remedies showed an inhibition concentration of Plasmodium growth of 83% (12.5 6g/ml) for C. occidentalis Linn., 91% (25 6g/ml) for C. Papaya Linn., 93% (25 6g/ml) for C. citratus (DC.) Staff, 1906, 93% (25 6g/ml) for L. camara L., 100% (12.5 6g/ml) for O. gratissimum L., 100% (12.56g/ml) for P. niruri L. and 0% (25 6g/ml) for V. amygdalina Delile. Secondary metabolites were isolated from some plant remedies and their IC50 determined in vitro on P. falciparum. The highest IC50 was observed in alkaloid extract of P. niruri L. (8 6g/ml); terpenes extract of O. gratissimum L. (0.276g/ml); quinone extract of G. kola Heckel. (1.02 6g/ml) and flavonoid extract of G. kola Heckel. (1.56g/ml).